- The Mass Transit Railway (MTR) is a major public transport network serving Hong Kong.Operated by the MTR Corporation Limited (MTRCL), it consists of heavy rail, light rail, and feeder bus service centred on an 11-line rapid transit network serving the urbanised areas of Hong Kong Island, Kowloon, and the New Territories.The system included 230.9 km (143.5 mi) of rail in 2018 with 163 stations.
- Located in New York and California, the Paley Center founded by William S. Paley is the world's foremost institution dedicated to collect and preserve the best of television and radio programming and advertising.
- The IV-MTR application: Provides end-to-end mail tracking information for letter and flat pieces, bundles, handling units, and containers. Leverages intelligence to create logical and assumed handling events to provide expanded visibility. Improves ease of use through flexible data provisioning and delegation.
Normal Function
Find the latest Mesa Royalty Trust (MTR) stock quote, history, news and other vital information to help you with your stock trading and investing. Now that we have seen the two utilities that make up MTR, let us now look at What MTR is. Unlike Ping and Traceroute which are enabled by default on most systems, MTR may need to be installed on the system you want to use. Note: Installation guide for different operating systems can be found here.
The MTR gene provides instructions for making an enzyme called methionine synthase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Specifically, methionine synthase carries out a chemical reaction that converts the amino acid homocysteine to another amino acid called methionine. The body uses methionine to make proteins and other important compounds. To function properly, methionine synthase requires methylcobalamin (a form of vitamin B12) and another enzyme called methionine synthase reductase, which is produced from the MTRR gene.
Health Conditions Related to Genetic Changes
Homocystinuria
More than 20 mutations in the MTR gene have been identified in people with homocystinuria. Many of these mutations lead to the production of an abnormally small, nonfunctional version of methionine synthase. Other mutations change single amino acids in the enzyme. One of the most common mutations replaces the amino acid proline with the amino acid leucine at position 1173 (written as Pro1173Leu or P1173L), resulting in an enzyme with reduced function. Without functional methionine synthase, homocysteine cannot be converted to methionine. As a result, homocysteine builds up in the bloodstream, and the amount of methionine is reduced. Some of the excess homocysteine is excreted in urine. Researchers have not determined how altered levels of homocysteine and methionine lead to the health problems associated with homocystinuria.
More About This Health ConditionOther disorders
A specific version (variant) of the MTR gene has been associated with various health problems before birth. The variant replaces one building block of DNA (nucleotide) called adenine with the nucleotide guanine at position 2756 in the MTR gene (written as A2756G). This variant has been associated with an increased risk of birth defects that occur during the development of the brain and spinal cord (neural tube defects). Some studies have suggested that the variant also increases the risk of having a child with Down syndrome, which is a condition characterized by intellectual disability and associated health problems, but other studies found no increased risk. Researchers do not know why there may be a connection between the A2756G variant of the MTR gene and the risk of neural tube defects or Down syndrome. Many factors play a part in determining the risk of these complex disorders.
Other Names for This Gene
Mtr Foods
- 5-methyltetrahydrofolate-homocysteine methyltransferase 1
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- cblG
- cobalamin-dependent methionine synthase
- Homocysteine-methyl tetrahydrofolate methyltransferase
- METH_HUMAN
- Methionine Synthase
- Tetrahydropteroylglutamate Methyltransferase
Additional Information & Resources
Tests Listed in the Genetic Testing Registry
Mtrs Retirement Plus
- Tests of MTR
Catalog of Genes and Diseases from OMIM
References
Mtravel Login
- Bosco P, Guéant-Rodriguez RM, Anello G, Barone C, Namour F, Caraci F, RomanoA, Romano C, Guéant JL. Methionine synthase (MTR) 2756 (A --> G) polymorphism,double heterozygosity methionine synthase 2756 AG/methionine synthase reductase(MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having achild with Down syndrome. Am J Med Genet A. 2003 Sep 1;121A(3):219-24. Citation on PubMed
- Carmel R, Green R, Rosenblatt DS, Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program. 2003:62-81. Review. Citation on PubMed
- Doolin MT, Barbaux S, McDonnell M, Hoess K, Whitehead AS, Mitchell LE.Maternal genetic effects, exerted by genes involved in homocysteineremethylation, influence the risk of spina bifida. Am J Hum Genet. 2002Nov;71(5):1222-6. Epub 2002 Oct 9. Citation on PubMed or Free article on PubMed Central
- Guéant-Rodriguez RM, Rendeli C, Namour B, Venuti L, Romano A, Anello G, Bosco P, Debard R, Gérard P, Viola M, Salvaggio E, Guéant JL. Transcobalamin andmethionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett. 2003 Jul 3;344(3):189-92. Citation on PubMed
- Watkins D, Ru M, Hwang HY, Kim CD, Murray A, Philip NS, Kim W, Legakis H, Wai T, Hilton JF, Ge B, Doré C, Hosack A, Wilson A, Gravel RA, Shane B, Hudson TJ,Rosenblatt DS. Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a commonmutation, P1173L. Am J Hum Genet. 2002 Jul;71(1):143-53. Epub 2002 May 30. Citation on PubMed or Free article on PubMed Central
